Professor Han Mi-ryeong and Joo Hye-yeon of Incheon National University's Molecular & Medical Science major

Joo Hye-yeon, a life sciences student at Incheon National University (Director: Han Mi-ryeong) presented a target for the diagnosis and treatment of recurrent and non-recurrent high-grade serous ovarian cancer through imaging dielectric analysis that combined spatial transcript data and CT image data. The findings were published in a paper (Title: Integrated Analysis of Spatial Transcriptomics and CT phenotypes for uncovering the novel molecular characteristics of recurrent and non-recurrent high-grade serous ovarian cancer) in the renowned international journal Biomarker Research (IF 11.1, JCR Top 6.6%).

In order to analyze the tumor microenvironment of recurrent and non-recurrent high-grade serous ovarian cancer, spatial transcript data were analyzed by integrating them with CT image data and public single-cell RNA sequencing data. We distinguished the tissue location rich in ovarian cancer-specific cell populations and found prognostic predictive markers that correlate with CT phenotype and recurrence. In conclusion, this study suggests that we can make an important contribution to the development of customized medicine by discovering diagnostic and therapeutic targets through imaging genomic research using spatial transcriptomes.

This study was conducted with a research team led by Professor Yoon-jin Choi of the Catholic University of Korea's St. Mary's Hospital, and was conducted with the support of the Korea Research Foundation.

Research Data of Professor Han Mi-ryeong's Research Team